A new class of artificial nucleases that recognize and cleave apurinic sites in DNA with great selectivity and efficiency

DOI: 10.1021/ja00075a011

Source and publish data:

Journal of the American Chemical Society p. 9952 - 9959 (1993)

Update date:2022-08-24

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Authors:

Fkyerat, Abdellatif

Demeunynck, Martine

Constant, Jean-Fran?ois

Michon, Pierre

Lhomme, Jean

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Article abstract of DOI:10.1021/ja00075a011

A series of tailor-made molecules, 1 and 4-7, have been prepared to recognize and cleave DNA at apurinic sites. These molecules incorporate in their structure different units designed for specific functions: (1) an intercalator for DNA binding, (2) a nucl

Full text of DOI:10.1021/ja00075a011

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