124495-03-0Relevant articles and documents
Lewis acid-catalyzed generation of C-C and C-N bonds on π-deficient heterocyclic substrates
Staderini, Matteo,Bolognesi, Maria Laura,Menndez, J. Carlos
, p. 185 - 195 (2015)
Focused microwave irradiation of a series of halogenated nitrogen heterocycles and different kinds of nucleophiles in the presence of a catalytic amount of indium trichloride leads to the efficient and completely regioselective generation of aromatic C-C and C-N bonds. The method is simple, rapid, general and inexpensive, and can be performed without the use of dried solvents. Most of the synthetized compounds are new and in many cases the work-up required only filtration. Furthermore, this is the first example of the use of a Lewis acid as a catalyst for heteroarylation, vinylation and amination reactions on π-deficient heterocyclic substrates.
A new class of artificial nucleases that recognize and cleave apurinic sites in DNA with great selectivity and efficiency
Fkyerat, Abdellatif,Demeunynck, Martine,Constant, Jean-Fran?ois,Michon, Pierre,Lhomme, Jean
, p. 9952 - 9959 (1993)
A series of tailor-made molecules, 1 and 4-7, have been prepared to recognize and cleave DNA at apurinic sites. These molecules incorporate in their structure different units designed for specific functions: (1) an intercalator for DNA binding, (2) a nucl
SYNTHESIS OF N-ACRIDINYL AND N-QUINOLINYL DERIVATIVES OF RADIOPROTECTIVE AMINO-THIOLS
Demonchaux, Patrice,Laayoun, Ali,Demeunynck, Martine,Lhomme, Jean
, p. 6455 - 6466 (2007/10/02)
A series of bifunctional molecules in which a heterocycle is linked to an aminothiol chain were synthesized.A new synthesis of N,N'-bis-(3-aminopropyl) cystamine (WR 33278) is descrided.Reaction of WR 33278 or analogues with the phenoxy derivatives of qui
