P-(Alkyl)-nucleoside 5′-hydrogenphosphonates as depot forms of antiviral nucleotide analogues

Article abstract of DOI:10.1080/15257770008045461

P-(Alkyl)esters of AZT 5′-hydrogenphosphonate were synthesized and their stabilities in the phosphate buffer and human serum were evaluated. The esters bearing residues of primary and secondary alcohols were degraded to give AZT, whereas those containing tertiary alkyl groups yielded AZT 5′-hydrogenphosphonate. The corresponding derivatives of d2A and d2T showed the same properties.

Full text of DOI:10.1080/15257770008045461

Nucleosides, Nucleotides and Nucleic Acids
ISSN: 1525-7770 (Print) 1532-2335 (Online) Journal homepage: http://www.tandfonline.com/loi/lncn20
P-(Alkyl)-Nucleoside 5′-Hydrogenphosphonates as
Depot Forms of Antiviral Nucleotide Analogues
A. L. Khandazhinskaya , E. A. Shirokova , I. L. Karpenko , N. F. Zakirova , N. B.
Tarussova & A. A. Krayevsky
To cite this article: A. L. Khandazhinskaya , E. A. Shirokova , I. L. Karpenko , N. F. Zakirova , N.
B. Tarussova & A. A. Krayevsky (2000) P-(Alkyl)-Nucleoside 5′-Hydrogenphosphonates as Depot
Forms of Antiviral Nucleotide Analogues, Nucleosides, Nucleotides and Nucleic Acids, 19:10-12,
1795-1804, DOI: 10.1080/15257770008045461
To link to this article: http://dx.doi.org/10.1080/15257770008045461
Published online: 17 Apr 2008.
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Date: 05 November 2015, At: 20:43