Synthetic Communications p. 2163 - 2170 (2020)
Update date:2022-08-11
Topics:
Jaganmohan, Chikkanti
Vinay Kumar
Venkateshwarlu
Mohanty, Sandeep
Kumar, Jaydeep
Venkateswara Rao
Raghunadh, Akula
Tadiparthi, Krishnaji
A new metal-free and modular approach for the synthesis of various functionalized dihydroquinazolinones has been developed from isatoic anhydride, amines, 4-chloro-N-hydroxybenzimidoylchloride to yield up to 71%. The reaction has been screened in various bases, solvents at different temperatures. The substrate scope of the reaction has been studied with various amines and the possible reaction mechanism for this reaction has also been proposed.
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