Journal of the Chemical Society, Dalton Transactions p. 1127 - 1132 (1987)
Update date:2022-08-11
Topics:
Miyamura, Kazuo
Hata, Kazuhiko
Makino, Tadashi
Saburi, Masahiko
Yoshikawa, Sadao
The reaction of bis<(3S)-3-aminopiperidine>copper(II) with but-3-en-2-one in methanol in the presence of ammonia gives an optically active tetra-azamacrocyclic comlex in ca. 80percent yield.Analogous optically active complexes are also obtained from bis<(3S)-3-aminohexahydroazepine>copper(II) or bis<(2S)-2-(aminomethyl)pyrrolidine>copper(II) by the same procedure.The introduction of methyl and/or a hydroxyl group at the C4 position of but-3-en-2-one leads to a decrease in the reactivity of the ketones, and changes the species and distribution of the reaction products.In particular, when the C4 position is fully substituted with methyl groups, C-N bond formation with the secondary amino group no longer proceeds.The change in the reaction mode due to the substituents at C4 is discussed.
View MoreChengdu King-tiger Pharm-chem. Tech. Co., Ltd
Contact:028-85317716
Address:Tianfu Life Science Park, No. 88 South Keyuan Road, Gaoxin District, Chengdu City, Sichuan Province, PRC.
Tianjin Pharmacn Medical Technology Co.,Ltd.
Contact:86-22-60122566ext.866(English),23359620
Address:Green Industrial Base, 6 Haitaifazhan Sixth Rd., Huayuan Industrial Area, Tianjin, 300384, China
Nanjing HuiBaiShi Biotechnology Co.,Ltd.
Contact:+86 (25)58745219
Address:No.606 Ningliu Road,LiuHe District.
Synchem Pharma Co.,Ltd(expird)
Contact:+0086-21-61984905-1
Address:Building 60,Zimian Park, LongYang industrial Area, 1515Nong，Yuandong Road Fengxian District, Shanghai ,China
Shijiazhuang Haitian Amino Acid Co., Ltd.
Contact:+86-311-88908111
Address:Shijiazhuang Hebei province,China
Doi:10.1021/bi00764a026
(1972)Doi:10.1016/j.tet.2016.04.069
(2016)Doi:10.1021/ja01244a050
(1943)Doi:10.1055/s-2006-926275
(2006)Doi:10.1021/jo00252a004
(1988)Doi:10.1016/j.steroids.2018.07.004
(2018)
