A convenient synthesis of masked β-ketoaldehydes by the controlled addition of nucleophiles to (trimethylsilyl)ethynyl ketones

Article abstract of DOI:10.1080/00397919308009803

The controlled addition of nucleophiles to (trimethylsilyl)ethynyl ketones provides a facile route to β-ketoacetals, β-alkoxy-α,β-unsaturated ketones or vinylogous amides depending on the choice of reaction conditions.

Full text of DOI:10.1080/00397919308009803

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Synthetic Communications: An
International Journal for Rapid
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Organic Chemistry
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A Convenient Synthesis of
Masked β-Ketoaldehydes
by the Controlled Addition
of Nucleophiles to
(Trimethylsilyl)ethynyl Ketones
S. M. Bromidge a , D. A. Entwistle b , J. Goldstein b
& B. S. Orlek a
a Smith Kline Beecham Pharmaceuticals, Medicinal
Research Centre, Coldharbour Road, The Pinnacles,
Harlow, Essex, CM19 5AD, England
b Imperial College of Science and Technology, Prince
Consort Road, London, SW7 2AZ, England
Version of record first published: 23 Sep 2006.
To cite this article: S. M. Bromidge , D. A. Entwistle , J. Goldstein & B. S. Orlek
(1993): A Convenient Synthesis of Masked β-Ketoaldehydes by the Controlled Addition
of Nucleophiles to (Trimethylsilyl)ethynyl Ketones, Synthetic Communications: An
International Journal for Rapid Communication of Synthetic Organic Chemistry, 23:4,
487-494
To link to this article: http://dx.doi.org/10.1080/00397919308009803
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