Marine Toxins of Latrunculia magnifica

Article abstract of DOI:10.1021/jo00168a028

Latrunculins A (1) and B (2) are the major extractable toxins of Latrunculia magnifica, constituting up to O.35 percent of the dry weight of the sponge.The structure of the compounds was determined by detailed spectral analysis, some minor chemical transformations, and X-ray crystallography.The latrunculins are the first-known 2-thiazolidinone-bearing marine macrolides.They were found to cause major alterations in specific cytoskeletal proteins.A retrosynthesis of the new compounds is suggested.