Solid phase synthesis of 2',5'-oligoadenylates containing 3'-fluorinated ribose

Article abstract of DOI:10.1080/15257779508010689

2',5'-phosphodiester bond-linked oligoadenylate trimers with 3'-fluoro- 3'-deoxyadenosine residues incorporated at specific positions of the nucleotide sequence were synthesized by the solid phase phosphite triester (phosphoramidite) method. The syntheses were in the 2' to 5' direction and were performed manually using commercially available microcolumns. The oligonucleotides were 5'-end phosphorylated on the support before deprotection.

Full text of DOI:10.1080/15257779508010689

This article was downloaded by: [Universitaetsbibliothek Giessen]
On: 24 October 2014, At: 01:31
Publisher: Taylor & Francis
Informa Ltd Registered in England and Wales Registered Number: 1072954 Registered
office: Mortimer House, 37-41 Mortimer Street, London W1T 3JH, UK
Nucleosides and Nucleotides
Publication details, including instructions for authors and
subscription information:
http://www.tandfonline.com/loi/lncn19
Solid Phase Synthesis of 2′, 5′-
Oligoadenylates Containing 3′-
Fluorinated Ribose
Teréz Kovács a , Arthur Van Aerschot b , Piet Herdewijn b & Paul
F. Torrence a
a fiiomedical Chemistry Section, Laboratory of Medicinal
Chemistry , National Institute of Diabetes and Digestive and
Kidney Diseases, NIH , Bethesda, MD, 20892
b Laboratory of Medicinal Chemistry , Rega Institute for Medical
Research , Minderbroedersstraat 10, B-3000, Leuven, Belgium
Published online: 24 Sep 2006.
To cite this article: Teréz Kovács , Arthur Van Aerschot , Piet Herdewijn & Paul F. Torrence (1995)
Solid Phase Synthesis of 2′, 5′-Oligoadenylates Containing 3′-Fluorinated Ribose, Nucleosides and
Nucleotides, 14:6, 1259-1267, DOI: 10.1080/15257779508010689
To link to this article: http://dx.doi.org/10.1080/15257779508010689
PLEASE SCROLL DOWN FOR ARTICLE
Taylor & Francis makes every effort to ensure the accuracy of all the information (the
“Content”) contained in the publications on our platform. However, Taylor & Francis,
our agents, and our licensors make no representations or warranties whatsoever as to
the accuracy, completeness, or suitability for any purpose of the Content. Any opinions
and views expressed in this publication are the opinions and views of the authors,
and are not the views of or endorsed by Taylor & Francis. The accuracy of the Content
should not be relied upon and should be independently verified with primary sources
of information. Taylor and Francis shall not be liable for any losses, actions, claims,
proceedings, demands, costs, expenses, damages, and other liabilities whatsoever
or howsoever caused arising directly or indirectly in connection with, in relation to or
arising out of the use of the Content.
This article may be used for research, teaching, and private study purposes. Any
substantial or systematic reproduction, redistribution, reselling, loan, sub-licensing,
systematic supply, or distribution in any form to anyone is expressly forbidden. Terms

& Conditions of access and use can be found at http://www.tandfonline.com/page/
terms-and-conditions