Highly diastereoselective addition of silyl enolates to chiral imines derived from (S)-valine methyl ester using lanthanide triflate

Article abstract of DOI:10.1016/0040-4039(96)00108-6

One-pot highly diastereoselective synthesis of β-amino esters, precursors of β-amino acids and β-lactam antibiotics has been accomplished starting from an aldehyde, a chiral amine and a silyl enolate using Yb(OTf)₃ as a catalyst at room tempera