H. Erer et al. / Polyhedron 28 (2009) 3087–3093
3093
Table 6
Antimicrobial assays of same antibiotics against wild type and clinical isolates by disc diffusion method (diameter in mm).
Wild type strains
C (30
l
g)
OFX (5
l
g)
RD (2
l
g)
CXM (30
l
g)
TE (30
lg)
N (10 lg)
S. aureus
B. cereus
E. coli
P. aeruginosa
C. albicans
20
23
28
21
–
27
24
30
17
–
27
9
9
18
–
16
–
23
17
–
30
28
27
20
–
–
–
–
–
24
Clinic isolates
MRSA
P. aeroginosa
22
–
–
21
–
–
–
–
13
18
–
–
C: chloramphenicol, OFX: oflaxacin, RD: rifampicin, CXM: cefuroxime, TE: tetracycline, N: nystatin.
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presence of metal ions plays an important role at antimicrobial
activity. We think that the disparity at antimicrobial activities be-
tween complexes on the microorganisms is change bond charac-
teristics on target area of metal ions because of identical
molecular structures of 1–8. Orotic acid and metal complexes have
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The results of our study indicate that clinic isolates are more
resistant than wild type microorganism at standard antibiotics (Ta-
ble 6). It is a well-known fact that hospital infections are quite
important for the public healthy and quite resistant against stan-
dard antibiotics. Therefore, there is an urgent demand for new
antibiotics and new classes of chemical formula that will efficiently
inhibit the growth of pathogenic microorganism. In this study, as
part of our efforts into the development of new metal based anti-
microbial complexes, new complex 4 could be a new candidate
for therapy of S. aureus infections and 5 could be candidate for
therapy of candidal infection diseases.
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Acknowledgment
[35] O.Z. Yesßilel, H. Ölmez, I. Uçar, A. Bulut, C. Kazak, Z. Anorg. Allg. Chem. 631
(2005) 3100.
This work was supported by the Eskißsehir Osmangazi Univer-
sity by Project No. 200819042.
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Appendix A. Supplementary data
_
Supplementary data associated with this article can be found, in
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