TOTAL SYNTHESIS OF (+/-)-α-ALLOKAINIC ACID VIA TWO ALLYLSILANE N-ACYLIMINIUM ION REACTIONS

DOI: 10.1016/S0040-4020(01)86407-3

Source and publish data:

Tetrahedron p. 3451 - 3462 (1991)

Update date:2022-08-28

Topics:

Authors:

Mooiweer, Hendrik H.

Hiemstra, Henk

Speckamp, W. Nico

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Article abstract of DOI:10.1016/S0040-4020(01)86407-3

A total synthesis of racemic α-allokainic acid is described, which starts from allylsilane 8 and methoxy- or chloroglycine derivative 9, and proceeds fully stereoselectively in nine steps and 1.1percent overall yield.Key steps are the intermolecular N-acy

Full text of DOI:10.1016/S0040-4020(01)86407-3

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