Practical synthesis of 4-aryl- and 4-heteroarylazetidin-2-ones: Applications in the synthesis of the Taxol side chain

Article abstract of DOI:10.1139/v94-270

A convenient, high-yielding procedure has been developed for the kilogram-scale synthesis of (±)-cis-3-acetoxy-4-phenylazetidin-2-one (3), a β-lactam that has been used in the semi-synthesis of Taxol. The Staudinger reaction between hydrobenzamide (5) and