Absolute Configuration of Thiazole Amino Acids in Peptides

Article abstract of DOI:10.1021/jo00161a039

A general method is presented for determining the absolute configuration of 2-(1-aminoalkyl)thiazole-4-carboxylic acids, based on the reaction of thiazoles with ¹O2.This newly developed method is used to assign the absolute coniguration o thiazole amino acids in the cytotoxic peptides isolated from the marine tunicate Lissoclinum patella.