RADIATION-INDUCED REDUCTIVE CONVERSION OF 5-BROMO-6-HYDROXYTHYMINE TO THYMINE PROMOTED BY TRANSITION METAL SALTS IN DEAERATED AQUEOUS SOLUTION

Article abstract of DOI:10.1246/cl.1983.1441

The radiation-induced reduction of 5-bromo-6-hydroxythymine to produce thymine (2) in deaerated aqueous solution was remarkably promoted by the addition of lower-valent transition metal salts (K4Fe(CN)6 (3a), CuCl (3b), K2PtCl6 (3c), and FeSO4 (3d)).It is suggested that the possible intermediate hydroxythymine-5-yl radical undergoes one-electron reduction by 3a-d to the corresponding anion which eliminates OH^- to produce 2.