An efficient synthesis of 2-trimethylsilyl-2-propenal, a useful three- carbon synthon

Article abstract of DOI:10.1080/00397919408013817

A formal efficient synthesis of 2-trimethylsilyl-2-propenal (2), a potentially useful synthetic reagent, is hereby described. The readily available α-bromovinyltrimethylsilane can be converted into 2- trimethylsilyl-2-propen-1-ol (1) via Grignard formation followed by addition of paraformaldehyde. The alcohol 1 can be oxidized using Jones reagent or PCC to yield the desired aldehyde 2.

Full text of DOI:10.1080/00397919408013817

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Synthetic Communications: An
International Journal for Rapid
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Organic Chemistry
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An Efficient Synthesis of 2-
Trimethylsilyl-2-propenal, A
Useful Three-Carbon Synthon
Richard P. Hsung a
a Searle Chemical Laboratories, Department of
Chemistry , The University of Chicago , IL 60637,
Chicago
Published online: 23 Sep 2006.
To cite this article: Richard P. Hsung (1994) An Efficient Synthesis of 2-
Trimethylsilyl-2-propenal, A Useful Three-Carbon Synthon, Synthetic Communications:
An International Journal for Rapid Communication of Synthetic Organic Chemistry,
24:2, 181-186, DOI: 10.1080/00397919408013817
To link to this article: http://dx.doi.org/10.1080/00397919408013817
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