Highly stereoselective induction in the cobalt-mediated [2+2+2] cycloaddition of chiral phosphine oxides substituted linear enediynes

Article abstract of DOI:10.1016/S0040-4039(99)01137-5

The cobalt(I)-catalyzed highly stereoselective [2+2+2] cyclization has been realized for the first time with chiral phosphine oxides substituted linear enediynes. Depending the substituents on the phosphorus atom, the cycloaddition was achieved with a lev