Design, synthesis and antiproliferative activity of methyl 4-iodo-1-β-D- ribofuranosyl-pyrazole-3-carboxylate and related compounds

Article abstract of DOI:10.1016/0960-894X(96)00216-8

In a SAR study on azole-related nucleosides we have designed some pyrazole-nucleoside analogs characterised, for the first time, by a carboxylic ester moiety. 4-Iodo-1-β-D-ribofuranosyl-pyrazole-3-carboxylate showed a wide spectrum of antiproliferative activity and a particularly low cytotoxicity against resting PBL, being, unlike the other azole nucleosides, more active than the corresponding primary amide.