Synthesis of tetrahydroquinolines from aromatic amines, formaldehyde and electron rich alkenes: Evidence for nonconcertedness

Article abstract of DOI:10.1016/0040-4039(91)85052-7

The one pot synthesis of Tetrahydroquinolines can be achieved by reaction of aromatic amines and formaldehyde with a variety of electron rich alkenes including styrenes and enol ethers. The cyclisation is multi-step as evidenced by the isolation of interm