XANTHONES, SECOIRIDOIDS AND FLAVANOIDS FROM HALENIA CORNICULATA

Article abstract of DOI:10.1016/0031-9422(95)00402-S

Three new xanthone glycosides and a rare flavonoid glycoside have been isolated from the whole plant methanolic extract of halenia corniculata (Gentianaceae).They were identified as 2,3,7-trimethoxy-1-O-primeverosyloxyxanthone, 2,3,4,7-tetramethoxy-1-O-primeverosyloxyxanthone, 2,3,4,5,7-pentamethoxy-1-O-primeverosyloxyxanthone and 7-O-primeverosylluteolin.Combined HPLC-UV and thermospray MS analyses of both dichloromethane and methanolic crude extracts permitted the detection of six other new xanthones, tentatively identified by on-line data.Among these, one was an aglycone, 1-hydroxy-2,3,4,5,7-pentamethoxyxanthone and five were 1-O-glycosides: 7-hydroxy-2,3,4,5-tetramethoxy-1-O-primeverosyloxyxanthone, 7-hydroxy-2,3,4,5-tetramethoxy-1-O-gentiobiosyloxyxanthone, 2,3,7-trimethoxy-1-O-gentiobiosyloxyxanthone, 2,3,4,7-tetramethoxy-1-O-gentiobiosyloxyxanthone and 2,3,4,5,7-pentamethoxy-1-O-gentiobiosyloxyxanthone.Systematic use of an in-house UVdatabase and complementary on-line MS data enabled the identification of 16 known secoiridoids, flavonoids and xanthones. - Keywords: Halenia corniculata; gentianaceae; xanthones; flavonoids; secoiridoids; aglycones; primeverosides; gentiobiosides; LC-UV; LC-TSP-MS.