STRUCTURE CHARACTERIZATION OF HAEMOSTATIC DIOSGENIN GLYCOSIDES FROM PARIS POLYPHYLLA

Article abstract of DOI:10.1016/S0031-9422(00)81066-3

Key Word Index - Paris polyphylla; Liliaceae; polyphyllin D; pariphyllin; yunnan paiyao; haemostatic and cytotoxic diosgenin glycosides. - From Paris polyphylla var. chinensis Hare (Liliaceae), four diosgenin glycosides with haemostatic effects were isolated.The structure of the major component was elucidated by chemical and spectroscopic methods as 3-(<α-L-rhamnopyranosyl(1_Rha -> 2_Glu)>-<α-L-arabinofuranosyl(1_Ara -> 4_Glu)>-β-D-glucopyranosyl)-25(R)-spirost-5-en-3β-ol.This saponin was found to be identical to three previously reported compounds to which other structures were originally assigned, namely the major component from P. polyphylla Smith, the major cytotoxic component of yunnan paiyao, and polyphyllin D from P. polyphylla grown in the Himalaya region.