Tetrahedron p. 9459 - 9464 (1993)
Update date:2022-08-16
Topics:
Nin, Alejandro P.
Varela, Oscar
De Lederkremer, Rosa M.
An expeditious synthesis of cis-4-hydroxypipecolic acid (1) is described. The key step was diastereoselective hydrogenation of 2-acetamido-6-O-acetyl-2,3,5-trideoxy-hex-2-enono-1,4-lactone (3), obtained in three high yielding steps from D-glucosamine. The
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Doi:10.1002/anie.201203189
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