Lipase-catalyzed Kinetic Resolution of Phenylcyclohexanone Oxime Esters

Article abstract of DOI:10.1016/S0957-4166(00)86277-1

Formation of optically active α or γ-phenylcyclohexanone oximes (2a and 2b, c) and their esters (1a and 3b, c) by lipase mediated transesterification of the corresponding racemic esters is described.Furthermore, 2(S)-phenyl and 2,2-dimethyl-4(R)-phenylcyclohexanones (4 and 5) were prepared without any racemization by treatment with dimethyldioxirane in acetone or sodium hydrogen sulfite in refluxing aqueous ethanol.