Interaction of 2-bromo-7-methyl-5-oxo-5H-1,3,4-thiadiazolopyrimidine with methylene-active compounds and acid hydrolysis of its products

Article abstract of DOI:10.1007/BF00699007

Reactions of 2-bromo-7-methyl-5-oxo-5H-1,3,4-thiadiazolo<3,2-a>pyrimidine with sodium derivatives of pentane-2,4-dione, malonodinitrile, Meldrum acid, acetoacetic, cyanoacetic and malonic esters have been shown to give the respective substituted derivatives.Azinyl-ylidene tautomerism has been found to be characteristic of these compounds, the latter existing mainly in the ylidene form.The acid hydrolysis of pentane-2,5-dione and cyanoacetic acid and malonic esters derivatives has been onvestigated. - Key words: nucleophilic substitution reaction, 2-bromo-7-methyl-5-oxo-5H-1,3,4-thiadiazolo<3,2-a>pyrimidine, methylene active compounds (pentane-2,5-dione, malonodinitrile, Meldrum acid, acetoacetic, cyanoacetic, malonic esters), azinyl-ylidene tautomerism, ketonic and acidic cleavage.