Synthesis and biochemical activity of hydrophilic carborane-containing pyrimidine nucleosides as potential agents for DNA incorporation and BNCT

Article abstract of DOI:10.1080/07328319708001357

A novel type of hydrophilic 5-tethered carborane-containing 2'- deoxyuridine derivative, SUB-7-DIOL, has been developed. This compound is a potential agent for DNA incorporation and BNCT, because it showed satisfactory aqueous solubility and demonstrated an excellent rate of phosphorylation by human thymidine kinase. This study also demonstrated the importance of tethering a flexible hydrocarbon chain between the carborane cage and the 5-position of the nucleoside, and the effectiveness of a water- solubilizing moiety attached to the carbon atom of the lipophilic carborane cage.

Full text of DOI:10.1080/07328319708001357

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Synthesis and Biochemical Activity
of Hydrophilic Carborane-Containing
Pyrimidine Nucleosides as Potential
Agents for DNA Incorporation and
BNCT
a
a
b
Feng-Guang Rong , Albert H. Soloway , Seiichiro Ikeda
&
b
David H. Ives
a
College of Pharmacy, The Ohio State University, 500 West 12th
Avenue, Columbus, OH, 43210, U.S.A.
b
College of Biological Sciences, The Ohio State University, 500
West 12th Avenue, Columbus, OH, 43210, U.S.A.
Published online: 21 Aug 2006.
To cite this article: Feng-Guang Rong , Albert H. Soloway , Seiichiro Ikeda & David H. Ives (1997):
Synthesis and Biochemical Activity of Hydrophilic Carborane-Containing Pyrimidine Nucleosides as
Potential Agents for DNA Incorporation and BNCT, Nucleosides and Nucleotides, 16:4, 379-401
To link to this article: http://dx.doi.org/10.1080/07328319708001357
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