Direct Conversion of Hydroxy Aromatic Compounds to Heteroarylamines via a One-Pot Smiles Rearrangement Procedure

DOI: 10.1002/jhet.5570340636

Source and publish data:

Journal of Heterocyclic Chemistry p. 1857 - 1860 (1997)

Update date:2022-08-29

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Authors:

Weidner, John J.

Peet, Norton P.

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Article abstract of DOI:10.1002/jhet.5570340636

8-Hydroxyquino line (9) was converted to 8-aminequinoline (10) in a one-pot procedure involving alkylation with 2-bromo-2-methylpropionamide (2) followed by Smiles rearrangement and hydrolysis, in 41% yield. The scope and limitations of this new procedure were explored with additional hydroxyquinolines.

Full text of DOI:10.1002/jhet.5570340636

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