Tetrahedron p. 5794 - 5799 (2014)
Update date:2022-08-25
Topics:
Chen, Xiaofei
Xiong, Fangjun
Zheng, Chen
Li, Jie
Chen, Fener
A concise and stereocontrolled synthesis of rosuvastatin calcium has been accomplished, with the key steps including a Keck enantioselective allylation of chloroacetaldehyde with allyltributylstannane to install 5R-stereocenter and a VO(acac)2-catalyzed syn-diastereoselective epoxidation of (S)-1-chloropent-4-en-2-ol to set the requisite 3R-chirality.
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