Studies on the constituents of edible and medicinal plants. III. Effects of seven limonoids on the sleeping time induced in mice by anesthetics

Article abstract of DOI:10.1248/cpb.40.3079

Effects of seven limonoids, obakunone (1), 7α-obakunol (2), 7β-obakunol (3), limonin (4), 7α-limonol (5), 7β-limonol (6) and nomilin (7), on the sleeping time induced in mice by anesthetics were assayed. All the limonoids, except for 2, shortened the sleeping time induced by α-chloralose and urethane. 7 gave the highest reduction rate of sleeping time, and the order of the reduction rate of sleeping time was as follows; 7 > 1 and 3 > 4, 5 and 6. As the chemical structures of these compounds are similar to each other, the relationship between the structure and the effects of limonoids on sleeping time was discussed.

Full text of DOI:10.1248/cpb.40.3079

NII-Electronic Library Service

NII-Electronic Library Service