Synthesis p. 819 - 820 (1996)
Update date:2022-08-29
Topics:
Braun, Manfred
Galle, Dietmar
The cholesterol absorption inhibitor (3R,4S)-1 is synthesized in 91% ee by a stereoselective condensation of doubly deprotonated ester 2 and imine 3. The optical purity of the trans-diastereomer 1 obtained as the major isomer (trans/cis, 94:6) is enhanced to >98% ee by a single recrystallization.
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Doi:10.1134/S107042801806009X
(2018)Doi:10.1021/jo01060a605
(1961)Doi:10.1021/ja01157a139
(1950)Doi:10.1039/c5ra07562a
(2015)Doi:10.1007/BF01302311
(1874)Doi:10.1002/cctc.201700381
(2017)
