Improved synthesis of anhydrohexitol building blocks for oligonucleotide synthesis

Article abstract of DOI:10.1002/jlac.199719970724

The synthesis of the four building blocks used for the preparation of hexitol nucleic acids were optimized. The nucleoside analogues with a purine base moiety are best prepared by a nucleophilic substitution reaction, whereas the pyrimidine nucleosides can best be obtained using Mitsunobu-type conditions. VCH Verlagsgesellschaft mbH, 1997.