SYNTHESIS AND STRUCTURAL STUDY OF N-(8-ISOPROPYL-NORTROPAN-3-α-YL)-2-METHOXY-4-AMINO-5-CHLOROBENZAMIDE

Article abstract of DOI:10.1016/0022-2860(88)87030-3

N-(8-Isopropyl-nortropan-3-α-yl)-2-methoxy-4-amino-5-chlorobenzamide has been synthesized and its crystal and molecular structures determined by X-ray diffraction, IR, 1H-NMR and 13C-NMR methods.The pyrrolidine and piperidine rings adopt a flattened N-8 envelope and distorted chair conformation puckered at N-8 and flattened at C-3 respectively, with the N-isopropyl substituent and the amido group in axial position with respect to the piperidine ring.A great predominance in solution of the conformer observed in the solid state is proposed.