Convergent synthesis of S-8921, a new potent hypocholesterolemic arylnaphthalene lignan analog

Article abstract of DOI:10.1016/S0040-4039(98)02554-4

We established a convergent synthesis of S-8921 (1), a unique hypocholesterolemic lignan analog, in 9 steps, including concise preparations of phthalide 7 and acylpropenoate 10, and their regio- and stereocontrolled tandem anionic reactions leading to precursor 11 as a key step.