A simple and efficient new approach to the total synthesis of (±)-4- amino-3-(4-chlorophenyl)-butyric acid (BACLOFEN)

Article abstract of DOI:10.1080/00397919708004109

Based on the utilization of a [2+21 cycloaddition reaction between dichloroketene and an appropriated olefin as a key step, we describe a new and simple four step approach to the total synthesis of (±)-4-amino-3-(4- chlorophenyl)-butyric acid (BACLOFEN),

Full text of DOI:10.1080/00397919708004109

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Synthetic Communications: An
International Journal for Rapid
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Organic Chemistry
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A Simple and Efficient
New Approach to the Total
Synthesis of (±)-4-Amino-3-
(4-Chlorophenyl)-Butyric Acid
(
BACLOFEN)
a
a
Fernando Coelho , Mariangela B. M. de Azevedo ,
a
a
Roberta Boschiero & Patrícia Resende
a
UNICAMP - Instituto de Química, Depto. de
Química Orgânica, P.O. Box 6154, 13083-970,
Campinas, SP, BRAZIL
Published online: 21 Aug 2006.
To cite this article: Fernando Coelho , Mariangela B. M. de Azevedo , Roberta
Boschiero & Patrícia Resende (1997): A Simple and Efficient New Approach to the
Total Synthesis of (±)-4-Amino-3-(4-Chlorophenyl)-Butyric Acid (BACLOFEN), Synthetic
Communications: An International Journal for Rapid Communication of Synthetic
Organic Chemistry, 27:14, 2455-2465
To link to this article: http://dx.doi.org/10.1080/00397919708004109
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