A new simple route to N,O-protected (S)-2-amino-4-oxobutyric acid

DOI: 10.1055/s-1993-26029

Source and publish data:

Synthesis p. 1225 - 1226 (1993)

Update date:2022-09-26

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Authors:

Dehmlow Dehmlow

Westerheide

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Article abstract of DOI:10.1055/s-1993-26029

Methionine is converted into the N,O-protected derivative 1b. Chlorination of 1b with sulfuryl chloride results in a mixture of the α-halosulfides 2a and 2b in the ratio of 6:1. Hydrolysis of 2a gives the title compound 3 in 64% yield.

Full text of DOI:10.1055/s-1993-26029

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