Nucleosides, nucleotides and nucleic acids p. 1017 - 1031 (2000)
Update date:2022-08-29
Topics:
Gavriliu
Fossey
Fontaine
Benzaria
Ciurea
Delbederi
Lelong
Laduree
Aubertin
Kirn
A general strategy is reported for the preparation of C-5-methylamino- or methyldiamino-d4t analogues of 'different sizes'. Reactions of the 2',3'- didehydro-2',3'-dideoxy-C-5 hydroxymethyl precursor (7) with either polymethylene diamines (n = 6, 8, 10 and 12) or propargylamine proceed regioselectively via substitution reactions at the C-5 position of uracil. The compounds were evaluated for antiviral activity and cytotoxicity. No significant activity was observed for compounds 9, 11, and 13, but 10 and 12 exhibited a weak activity against HIV-1.
View MoreSuZhou Bichal Biological Technology CO.,LTD
Contact:+86-512-68051130
Address:NO.32 huoju road HI-TECH Industrial development zone SuZhou China
Shanghai Witshoot Internet Technology Co Ltd
Contact:+86-21-66390020
Address:Room 419, No.285 Luochuan Road (E)
Shandong Hongxiang Zinc Co., Ltd
Contact:086-0311-66187879
Address:DaWang developing zone
Hunan Dinuo Pharmaceutical Co.,Ltd.
Contact:86-731-88280100*8561
Address:Bio-pharmaceutical industrial park, Liuyang, Hunan, China
Contact:+86-574-87642758
Address:Room 901, Yinyi Bund Building, 132 Renmin Road
Doi:10.1002/zaac.200300142
(2003)Doi:10.1039/c4ra00715h
(2014)Doi:10.1021/ja01286a512
(1937)Doi:10.1021/jacs.8b09715
(2019)Doi:10.1139/v87-243
(1987)Doi:10.3390/molecules21030333
(2016)