Stereoselective synthesis of 6-methyl-9-(2-deoxy-β-D-erythro- pentofuranosyl)purine

Article abstract of DOI:10.1080/07328319608002431

The coupling of the sodium salt of 6-methylpurine with 2-deoxy-3,5-di- O-p-toluoyl-α-D-erythro-pentofuranosyl chloride in acetonitrile gives the di-O-p-toluoyl protected 9-β nucleoside regio- and stereo-selectively in good yield. Methoxide deprotection followed by preparative hplc then affords pure 6-methyl-9-(2-deoxy-β-D-erythro-pentofuranosyl)purine.

Full text of DOI:10.1080/07328319608002431

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Nucleosides and Nucleotides
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Stereoselective Synthesis of 6-
Methyl-9-(2-Deoxy-β-D-Erythro-
Pentofuranosyl)purine
Janet E. Anderson-McKay a , Gerald W. Both b & Gregory W. Simpson
a
a CSIRO , Division of Chemicals and Polymers , Private Bag 10,
Rosebank MDC, Clayton, Victoria, Australia , 3169
b A CSIRO , Division of Biomolecular Engineering, Sydney
Laboratory , P. O. Box 184, North Ryde, New South Wales, Australia ,
2113
Published online: 22 Aug 2006.
To cite this article: Janet E. Anderson-McKay , Gerald W. Both & Gregory W. Simpson (1996)
Stereoselective Synthesis of 6-Methyl-9-(2-Deoxy-β-D-Erythro-Pentofuranosyl)purine, Nucleosides and
Nucleotides, 15:7-8, 1307-1313, DOI: 10.1080/07328319608002431
To link to this article: http://dx.doi.org/10.1080/07328319608002431
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