Organic Letters
Letter
ORCID
also facilitate the reaction between allyl ketone 1a and β,γ-
unsaturated α-ketoester 2ab, furnishing 3ab with excellent 98%
ee (Scheme 4, eq 5).
Author Contributions
¶X.L. and X.K. contributed equally.
The diverse functional groups within the products enable
facile and valuable further transformations. For instance, the
oxidation of 3a by m-CPBA allowed access to substituted
tetrahydropyran 4a in moderate yield,9 and the following
reaction using DMP/NaHCO3 afforded fully substituted
lactone 5a in 60% yield with 95% ee, probably through a
rearrangement.10 Moreover, the selective reduction of the
unsaturated ketone moiety of 3a under copper catalysis using
PhSiH3 led to the formation of 6a with 90% ee (Scheme 5).
Notes
The authors declare no competing financial interest.
ACKNOWLEDGMENTS
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This work was supported by National Natural Science
Foundation of China (Grants 21871260 and 21502192), the
strategic priority research program of the Chinese Academy of
Sciences (XDB20000000), the Chinese Recruitment Program
of Global Experts, Fujian Natural Science Foundation
(2018J05035), and China Postdoctoral Science Foundation
(2018M630734).
Scheme 5. Derivatizations of Product 3a
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ASSOCIATED CONTENT
* Supporting Information
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S
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Accession Codes
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AUTHOR INFORMATION
Corresponding Authors
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