A concise stereocontrolled total synthesis of (+)-estrone

Article abstract of DOI:10.1016/S0040-4039(00)74175-X

(+)-Estrone (1) has been synthesized in diastereo- and regioselective manners in six steps in 28% overall yield (38% based on the consumed material) starting from (-)-dicyclopentadienone (2) by employing a Diels-Alder cycloaddition-cycloreversion as the key step.