The dealkylation of tertiary aliphatic amines with phenyl chlorothionoformate

DOI: 10.1016/S0040-4039(98)00743-6

Source and publish data:

Tetrahedron Letters p. 4387 - 4390 (1998)

Update date:2022-08-28

Topics:

Authors:

Millan, David S.

Prager, Rolf H.

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Article abstract of DOI:10.1016/S0040-4039(98)00743-6

Phenyl chlorothionoformate reacts reacts rapidly with aliphatic amines at 20°C to give a thiourethane and an alkyl chloride. The urethanes are readily converted to the secondary amine salt by reaction with dimethyl sulfate, followed by hydrolysis with wat

Full text of DOI:10.1016/S0040-4039(98)00743-6

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