Journal of Pharmaceutical Sciences p. 1699 - 1701 (1976)
Update date:2022-08-11
Topics:
Hirata
Driscoll
Four phenothiazine derivatives containing the bis (β chloroethyl) aminopropyl side chain were prepared and evaluated in the murine L 1210, P 388 and B 16 melanoma intraperitoneal tumor systems. Moderate P 388 activity was observed. An aminoethyl phenothiazine mustard was compared with the aminopropyl analogs and was superior in all test systems. None of the compounds tested against the murine ependymoblastoma brain tumor system was active.
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