77-37-2 Usage
Uses
Antiparkinsonian; relaxant (skeletal
muscle).
Definition
ChEBI: A tertiary alcohol that consists of propan-1-ol substituted by a cyclohexyl and a phenyl group at position 1 and a pyrrolidin-1-yl group at position 3.
Synthesis
Procyclidine, 1-cyclohexyl-1-phenyl-3-pirrolidinopropan-1-ol (10.2.3), is
synthesized in the exact same manner, except beginning with 2-(1-pyrrolidino) propiophenone [28–32].
Check Digit Verification of cas no
The CAS Registry Mumber 77-37-2 includes 5 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 2 digits, 7 and 7 respectively; the second part has 2 digits, 3 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 77-37:
(4*7)+(3*7)+(2*3)+(1*7)=62
62 % 10 = 2
So 77-37-2 is a valid CAS Registry Number.
InChI:InChI=1/C19H29NO/c21-19(17-9-3-1-4-10-17,18-11-5-2-6-12-18)13-16-20-14-7-8-15-20/h1,3-4,9-10,18,21H,2,5-8,11-16H2
77-37-2Relevant articles and documents
Aryl-cycloalkyl-alkanolamines for treatment of cholinergic neurotoxins
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, (2008/06/13)
A compound and method are disclosed for reducing neurotoxic effects (such as seizures and brain damage) caused by cholinergic agents such as soman (a nerve gas) and pilocarpine (a convulsant drug used to study the mechanisms of epilepsy). Effective treatment can be provided by administering an aryl-cycloalkylalkanolamine substance having the general formula: STR1 The compoudns procyclidine, biperiden, and trihexyphenidyl fall within this class of compounds. Although not previously recognized to be effective against soman or other cholinergic neurotoxins, all three representative compounds have been discovered to be highly effective against all cholinergic neurotoxins tested to data, even when administered after actual seizures begin.
