Journal of Medicinal Chemistry p. 6649 - 6652 (2004)
Update date:2022-08-16
Topics:
Tomé, Jo?o P. C.
Neves, Maria G. P. M. S.
Tomé, Augusto C.
Cavaleiro, José A. S.
Soncin, Marina
Magaraggia, Michela
Ferro, Stefania
Jori, Giulio
Studies on the synthesis, structural elucidation, and biological evaluation of new conjugates of poly-S-lysine with meso-substituted porphyrins are described. The new conjugates were used in the photoinactivation of antibiotic-resistant Gram-positive bacteria (Staphylococcus aureus strains ATCC 25923 and MRSA 110) and Gram-negative bacteria (Escherichia coli strain O4). The results show that the cationic conjugates are able to photosensitize the efficient inactivation of both types of bacteria.
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