Stereochemical Studies on the Proposed Spiro Intermediate for the Biosynthesis of the Natural Porphyrins: Determination by a Novel X-Ray Method of the Absolute Configuration of the Spirolactam which Inhibits Cosynthetase

DOI: 10.1039/c39950001789

Source and publish data:

Journal of the Chemical Society. Chemical communications p. 1789 - 1790 (1995)

Update date:2022-08-11

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Authors:

Spivey, Alan C.

Capretta, Alfredo

Frampton, Christopher S.

Leeper, Finian J.

Battersby, Alan R.

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Article abstract of DOI:10.1039/c39950001789

A novel X-ray analysis, combined with correlations by circular dichroism, has been used to establish the (R)-configuration at the stereocentre in that enantiomer of the spirolactam 4 which strongly inhibits uroporphyrinogen III synthase.

Full text of DOI:10.1039/c39950001789

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