Enantiospecific total synthesis of tryprostatin A

Article abstract of DOI:10.1016/S0040-4039(97)00077-4

The 3-methyl-6-methoxyindole 3 was converted into tryprostatin A (1) via a regiospecific bromination process coupled with the Schollkopf chiral auxillary 7 to provide the 2-bromo-6-methyoxytryptophan 8a as a key intermediate.