An efficient general synthesis of 1-amino-2-naphthalenecarboxylic acid derivatives based on a tandem conjugate addition-enolate nitrile coupling sequence

Article abstract of DOI:10.1246/cl.1996.25

Reaction of o-(α-lithioalkyl)benzonitriles with α,β-unsaturated carboxylic acid derivatives produced 1-amino-3,4-dihydro-2-naphthalenecarboxylic acid derivatives through the tandem conjugate addition-enolate nitrile coupling sequence, which in turn were c