Alternative synthesis of duocarmycin SA using a tricyclic heteroaromatic intermediate prepared by palladium-catalyzed coupling reactions

DOI: 10.1248/cpb.44.1631

Source and publish data:

Chemical and Pharmaceutical Bulletin p. 1631 - 1633 (1996)

Update date:2022-08-29

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Authors:

Muratake, Hideaki

Tonegawa, Miyuki

Natsume, Mitsutaka

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Article abstract of DOI:10.1248/cpb.44.1631

Alternative synthesis of duocarmycin SA (1) was achieved by developing a novel preparation method using palladium catalysts for a tricyclic heteroaromatic compound 4b, followed by transformation into the previously reported intermediates 13 and 14a by way of the alcohol 10b.

Full text of DOI:10.1248/cpb.44.1631

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