Anti-inflammatory Exploration of Sulfonamide Containing Diaryl Pyrazoles with Promising COX-2 Selectivity and Enhanced Gastric Safety Profile

DOI: 10.1002/jhet.3118

Source and publish data:

Journal of Heterocyclic Chemistry p. 913 - 922 (2018)

Update date:2022-08-11

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Authors:

Pavase, Laxmikant S.

Mane, Dhananjay V.

Baheti, Kamalkishor G.

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Article abstract of DOI:10.1002/jhet.3118

Novel sulfonamide containing diaryl pyrazoles were synthesized and were subsequently tested for their in vitro cyclooxygenase inhibitory assay. Compounds that showed promising in vitro COX-2 IC₅₀ values and selectivity indices were then evaluat

Full text of DOI:10.1002/jhet.3118

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