Bioorganic and Medicinal Chemistry p. 4381 - 4389 (2016)
Update date:2022-08-24
Topics:
Sanllehí, Pol
Abad, José-Luis
Casas, Josefina
Bujons, Jordi
Delgado, Antonio
A series of potential active-site sphingosine-1-phosphate lyase (S1PL) inhibitors have been designed from scaffolds 1 and 2, arising from virtual screening using the X-ray structures of the bacterial (StS1PL) and the human (hS1PL) enzymes. Both enzymes ar
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