Paper
RSC Advances
stabilities of the polymorphs, and Hirshfeld analysis indicated 18 J.-R. Wang, B. Zhu, Z. Zhang, J. Bao, G. Deng, Q. Ding and
intermolecular interactions such as H/H, C/H, and H/O X. Mei, Cryst. Growth Des., 2017, 17, 3482.
contribute signicantly to the overall stability of the forms. This 19 D. Gur, M. Pierantoni, N. E. Dov, A. Hirsh, Y. Feldman,
study clearly indicates that thermal treatment of crystalline S. Weiner and L. Addadi, Cryst. Growth Des., 2016, 16, 4975.
samples could be an efficient approach for new polymorph 20 Polymorphism in Pharmaceutical Solids, ed. H. G. Brittain,
generation. We are currently attempting to obtain single crys-
Marcel Dekker, New York, 1999.
tals for form III.
21 S. R. Byrn, R. R. Pfeiffer and J. G. Stowell, Solid State
Chemistry of Drugs, SSCI, Inc., West Lafayette, IN, 2nd edn,
1999.
Conflicts of interest
2
2 D. K. Chalmers, G. H. Scholz, D. J. Topliss, E. Koliniatis,
S. L. Munro, D. J. Craik, M. Iskander and J. R. Stockigt, J.
Med. Chem., 1993, 36, 1272.
There are no conicts to declare.
2
3 J. S. Kaltenbrom, R. A. Scherrer, F. W. Short, H. R. Beatty,
M. M. Saka, C. V. Winder, J. Wax and W. R. Williamson,
Arzneim.-Forsch., 1983, 33, 621.
Acknowledgements
RH and SL thanks Natural Science Foundation of Hubei Prov-
ince (2014CFB787) and the President's Fund of Wuhan Institute 24 V. Dokorou, D. Kovala-Demertzi, J. P. Jasinskib, A. Galania
of Technology (CX2016075) for nancial support. PPZ and M. A. Demertzisa, Helv. Chim. Acta, 2004, 87, 1940.
acknowledges the nancial support by the National Natural 25 S. Long and T. Li, Cryst. Growth Des., 2010, 10, 2465.
Science Foundation of China (Grant No. 21403097) and the 26 S. Long, P. Zhou, S. Parkin and T. Li, Cryst. Growth Des.,
Fundamental Research Funds for the Central Universities
lzujbky-2016-45).
2014, 14, 27.
(
27 S. Long, S. Parkin, A. Siegler, C. Brock, A. Cammers and T. Li,
Cryst. Growth Des., 2008, 8, 9.
2
2
8 S. Long and T. Li, Cryst. Growth Des., 2009, 9, 4993.
9 S. Long, S. Parkin, M. A. Siegler, A. Cammers and T. Li, Cryst.
Growth Des., 2008, 8, 4006.
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