Studies on Carbohydrates XX. Synthesis of Hexasaccharide Containing Lactosamine Unit Using Glycosyl Trichloroacetates as Glycosyl Donors

Article abstract of DOI:10.1016/0040-4039(96)01989-2

O-Glycosyl trichloroacetate, a stable and readily obtained intermediate, was activated as a highly reactive glycosyl donor upon treatment with acid and coupled with the acceptor to afford complex glycosides with high stereoselectivity. - Key words: disaccharide; hexasaccharide; oligosaccharide; O-glycosyl trichloroacetate; tumor metastasis