Steroids p. 135 - 142 (1985)
Update date:2022-08-24
Topics:
Mittler, James C.
Microsomal preparations from adult male rat testicular interstitial cells were incubated with tritiated testosterone.Added 7α-hydroxytestosterone, (7α,17β-dihydroxy-4-androsten-3-one), at levels which appear to exist in the adult testis, inhibited production of labelled 5α-reduced steroids in a graded fashion.This interaction is not competitive and occurs only at high substrate levels, such as those found in steroid-producing organs.Relationships to pubertal changes in steroid metabolism are discussed.
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